Trygve Brautaset

Om

Trygve Brautaset er Professor i syntetisk biologi og har vært prosjektleder for ialt 5 ERA prosjekter, ett EU prosjekt, samt ledet flere nasjonale forskningsprosjekter. Han er Faggruppeleder for Mikrobiell Bioteknologi. Brautaset er leder for Senter for Digitalt Liv Norge, Nestleder i TSO Helse & Livsvitenskap, Nestleder i Bioteknologirådet. Brautaset brenner for Forskning og forskerutdanning, og har erfaring med industrisamvirke i forskninga gjennom 10 år i sintef, samt involvering i oppstartsbedrifter. Brautaset var medlem i Genteknologiutvalget og er ved siden av egen forskning også opptatt av forskningspolitikk.

Publikasjoner

2025

Irla, Marta Katarzyna; Nærdal, Ingemar; Virant, David; Brautaset, Trygve; Busche, Tobias; Goranovič, Dušan. (2025) Systems-level analysis provides insights on methanol-based production of L-glutamate and its decarboxylation product γ-aminobutyric acid by Bacillus methanolicus. Metabolic Engineering
Vitenskapelig artikkel

2024

Gamlund, Espen; Barra, Mathias; Brautaset, Trygve. (2024) Surrogati bør ikke straffes. Morgenbladet
Leserinnlegg
Perez Garcia, Fernando; Fernandes de Brito, Luciana; Bakken, Thea Isabel; Brautaset, Trygve. (2024) Riboflavin overproduction from diverse feedstocks with engineered Corynebacterium glutamicum. Biofabrication
Vitenskapelig artikkel
Bastem, Gülsüm Merve; Sayar, Nihat Alpagu; Fernandes de Brito, Luciana; Brautaset, Trygve; Virant, David; Sariyar Akbulut, Berna. (2024) Development of a novel process towards an L-malate biorefinery using methanol as feedstock. Chemical engineering research & design
Vitenskapelig artikkel
Klein, Vivien Jessica; Troøyen, Susanne Hansen; Fernandes de Brito, Luciana; Courtade, Gaston; Brautaset, Trygve; Irla, Marta Katarzyna. (2024) Identification and characterization of a novel formaldehyde dehydrogenase in Bacillus subtilis. Applied and Environmental Microbiology
Vitenskapelig artikkel

2023

Klein, Vivien Jessica; Fernandes de Brito, Luciana; Perez Garcia, Fernando; Brautaset, Trygve; Irla, Marta Katarzyna. (2023) Metabolic engineering of thermophilic Bacillus methanolicus for riboflavin overproduction from methanol. Microbial Biotechnology
Vitenskapelig artikkel
Bratlie, Sigrid; Alsheikh, Muath K; Brautaset, Trygve; Gamlund, Espen; Holst-Jensen, Arne; Tøndel, Camilla. (2023) Mer faglighet fra naturbevegelsen, takk. Klassekampen
Leserinnlegg
Bratlie, Sigrid; Holst-Jensen, Arne; Alsheikh, Muath K; Brautaset, Trygve; Gamlund, Espen; Tøndel, Camilla. (2023) På tide å åpne for genteknologi i norsk matproduksjon. Nationen
Kronikk
Bratlie, Sigrid; Tøndel, Camilla; Alsheikh, Muath K; Brautaset, Trygve; Gamlund, Espen; Holst-Jensen, Arne. (2023) GMO-regler må ikke få stoppe utviklingen av avanserte terapier. Dagens medisin
Kronikk
Gamlund, Espen; Alsheikh, Muath K; Bratlie, Sigrid; Brautaset, Trygve; Holst-Jensen, Arne; Tøndel, Camilla. (2023) Uetisk å la være å satse på genteknologi. Dagsavisen
Kronikk
Wargelius, Anna; Alsheikh, Muath K; Gamlund, Espen; Tøndel, Camilla; Bartmann, Aina; Holst-Jensen, Arne. (2023) Genteknologi i en bærekraftig fremtid. Genteknologiutvalget - Norsk Offentlig Utredning (NOU)
Rapport
Hesjedal, Maria Bårdsen; Brautaset, Trygve; Strand, Roger. (2023) Digital Life Norway - should biotechnology be transdisciplinary?. Edward Elgar Publishing
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel

2022

Perez-Garcia, Fernando; Klein, Vivien Jessica; Fernandes de Brito, Luciana; Brautaset, Trygve. (2022) From Brown Seaweed to a Sustainable Microbial Feedstock for the Production of Riboflavin. Frontiers in Bioengineering and Biotechnology
Vitenskapelig artikkel
Klein, Vivien Jessica; Irla, Marta Katarzyna; Gil Lopez, Marina; Brautaset, Trygve; Fernandes de Brito, Luciana. (2022) Unravelling Formaldehyde Metabolism in Bacteria: Road towards Synthetic Methylotrophy. Microorganisms
Vitenskapelig oversiktsartikkel/review

2021

Naderi, Sheida; Visnes, Torkild; Brautaset, Trygve. (2021) Impact of DNA glycosylases on epigenetic regulation of gene expression via active DNA demethylation in human cells. NTNU Open
Mastergradsoppgave
Wendisch, Volker F.; Kosec, Gregor; Heux, Stéphanie; Brautaset, Trygve. (2021) Aerobic Utilization of Methanol for Microbial Growth and Production. Advances in Biochemical Engineering, Biotechnology
Vitenskapelig oversiktsartikkel/review
Irla, Marta Katarzyna; Hakvåg, Sigrid; Brautaset, Trygve. (2021) Developing a riboswitch-mediated regulatory system for metabolic flux control in thermophilic bacillus methanolicus. International Journal of Molecular Sciences
Vitenskapelig artikkel
Fernandes de Brito, Luciana; Irla, Marta Katarzyna; Nærdal, Ingemar; Le, Simone Balzer; Baudoin, Delepine; Heux, Stéphanie. (2021) Evaluation of Heterologous Biosynthetic Pathways for Methanol-Based 5-Aminovalerate Production by Thermophilic Bacillus methanolicus. Frontiers in Bioengineering and Biotechnology
Vitenskapelig artikkel
Stenseth, Nils Christian; Baalsrud, Helle Tessand; Jakobsen, Kjetill Sigurd; Brautaset, Trygve; Goksøyr, Anders; Jensen, Nina. (2021) Havgenomet – bevaring og bærekraftig bruk av marine genetiske ressurser i Norge.
Faglig kapittel
Brautaset, Trygve. (2021) Genteknologisk vaksine gir nytt håp. Genialt - Tidsskrift fra Bioteknologirådet
Populærvitenskapelig artikkel
Khider, May Laura Kilano; Brautaset, Trygve; Irla, Marta Katarzyna. (2021) Methane monooxygenases: central enzymes in methanotrophy with promising biotechnological applications. World Journal of Microbiology & Biotechnology
Vitenskapelig artikkel

2020

Brautaset, Trygve; Jonassen, Inge; Bösl, Korbinian; Norunn K, Torheim. (2020) På tide å sette av fem prosent av prosjektmidlene til datahåndtering? . Khrono.no
Populærvitenskapelig artikkel
Drejer, Eivind Bøe; Chan, Dennis; Haupka, Carsten; Wendisch, Volker F.; Brautaset, Trygve; Irla, Marta Katarzyna. (2020) Methanol-based acetoin production by genetically engineered Bacillus methanolicus. Green Chemistry
Vitenskapelig artikkel
Gawin, Agnieszka Maria; Tietze, Lisa; Aarstad, Olav Andreas; Aachmann, Finn Lillelund; Brautaset, Trygve; Ertesvåg, Helga. (2020) Functional characterization of three Azotobacter chroococcum alginate-modifying enzymes related to the Azotobacter vinelandii AlgE mannuronan C-5-epimerase family. Scientific Reports
Vitenskapelig artikkel
Irla, Marta Katarzyna; Drejer, Eivind Bøe; Brautaset, Trygve; Hakvåg, Sigrid. (2020) Establishment of a functional system for recombinant production of secreted proteins at 50 °C in the thermophilic Bacillus methanolicus. Microbial Cell Factories
Vitenskapelig artikkel
Pfeifenschneider, Johannes; Markert, Benno; Stolzenberger, Jessica; Brautaset, Trygve; Wendisch, Volker F.. (2020) Transaldolase in Bacillus methanolicus: biochemical characterization and biological role in ribulose monophosphate cycle. BMC Microbiology
Vitenskapelig artikkel
Hakvåg, Sigrid; Nærdal, Ingemar; Heggeset, Tonje Marita Bjerkan; Kristiansen, Kåre Andre; Aasen, Inga Marie; Brautaset, Trygve. (2020) Production of Value-Added Chemicals by Bacillus methanolicus Strains Cultivated on Mannitol and Extracts of Seaweed Saccharina latissima at 50C. Frontiers in Microbiology
Vitenskapelig artikkel
Allahgholi, Leila; Sardari, Roya R.R.; Hakvåg, Sigrid; Ara, Kazi Z.G.; Kristjansdottir, Thordis Anna; Aasen, Inga Marie. (2020) Composition analysis and minimal treatments to solubilize polysaccharides from the brown seaweed Laminaria digitata for microbial growth of thermophiles. Journal of Applied Phycology
Vitenskapelig artikkel
Hans, Sebastian; Ulmer, Christian; Narayanan, Harini; Brautaset, Trygve; Krausch, Niels; Neubauer, Peter. (2020) Monitoring Parallel Robotic Cultivations with Online Multivariate Analysis. Processes
Vitenskapelig artikkel
Gawin, Agnieszka Maria; Ertesvåg, Helga; Hansen, Sine Alise Hartvigsen; Malmo, Jostein; Brautaset, Trygve. (2020) Translational regulation of periplasmic folding assistants and proteases as a valuable strategy to improve production of translocated recombinant proteins in Escherichia coli. BMC Biotechnology
Vitenskapelig artikkel

2019

Schultenkamper, Kerstin; Fernandes de Brito, Luciana; Lopez, Marina Gil; Brautaset, Trygve; Wendisch, Volker F.. (2019) Establishment and application of CRISPR interference to affect sporulation, hydrogen peroxide detoxification, and mannitol catabolism in the methylotrophic thermophile Bacillus methanolicus. Applied Microbiology and Biotechnology
Vitenskapelig artikkel
Gawin, Agnieszka; Peebo, Karl; Sebastian, Hans; Ertesvåg, Helga; Irla, Marta Katarzyna; Neubauer, Peter. (2019) Construction and characterization of broad-host-range reporter plasmid suitable for on-line analysis of bacterial host responses related to recombinant protein production. Microbial Cell Factories
Vitenskapelig artikkel
Nærdal, Ingemar; Pfeifenschneider, Johannes; Brautaset, Trygve; Wendisch, Volker F.. (2019) Corrigendum Methanol-based cadaverine production by genetically engineered Bacillus methanolicus strains. Microbial Biotechnology
Errata
Brautaset, Trygve; Valla, Svein. (2019) Special Issue: Recombinant Protein Expression in Microorganisms. Microorganisms
Short communication
Irla, Marta Katarzyna; Heggeset, Tonje Marita Bjerkan; Nærdal, Ingemar; Paul, Lidia; Haugen, Tone; Le, Simone Balzer. (2019) Corrigendum: Genome-Based Genetic Tool Development for Bacillus methanolicus: Theta- and Rolling Circle-Replicating Plasmids for Inducible Gene Expression and Application to Methanol-Based Cadaverine Production. Frontiers in Microbiology
Errata
Görbitz, Carl Henrik; Jakobsen, Kjetill Sigurd; Sandve, Simen Rød; Goksøyr, Anders; Brautaset, Trygve; Jørgensen, Trond Ø.. (2019) Den sjette masseutryddelse og Jordens DNA. Aftenposten (morgenutg. : trykt utg.)
Kronikk
Schultenkämper, Kerstin; Fernandes de Brito, Luciana; Gil López, Marina; Brautaset, Trygve; Wendisch, Volker F.. (2019) Establishment and application of CRISPR interference to affect sporulation, hydrogen peroxide detoxification, and mannitol catabolism in the methylotrophic thermophile Bacillus methanolicus. Applied Microbiology and Biotechnology
Vitenskapelig artikkel

2018

Johansen, Finn-Eirik; Brautaset, Trygve; Aune, Marie Hjelmseth; Patriksson, Alexandra; Falkenberg, Liv Eggset; Kleppe, Rune. (2018) Centre for Digital Life Norway - Annual report 2017. Senter for Digialt Liv Norge
Rapport
Drejer, Eivind Bøe; Hakvåg, Sigrid; Irla, Marta Katarzyna; Brautaset, Trygve. (2018) Genetic Tools and Techniques for Recombinant Expression in Thermophilic Bacillaceae. Microorganisms
Vitenskapelig oversiktsartikkel/review
Courtade, Gaston; Brautaset, Trygve; Aachmann, Finn Lillelund. (2018) An NMR investigation of lytic polysaccharide monooxygenases . Doktoravhandlinger ved NTNU (337)
Doktorgradsavhandling

2017

Irla, Marta; Nærdal, Ingemar; Brautaset, Trygve; Wendisch, Volker F.. (2017) Methanol-based γ-aminobutyric acid (GABA) production by genetically engineered Bacillus methanolicus strains. Industrial crops and products (Print)
Vitenskapelig artikkel
Courtade, Gaston; Le, Simone Balzer; Sætrom, Gerd Inger; Brautaset, Trygve; Aachmann, Finn Lillelund. (2017) A novel expression system for lytic polysaccharide monooxygenases. Carbohydrate Research
Vitenskapelig artikkel
Brautaset, Trygve. (2017) Bioteknologi. Fagbokforlaget
Faglig kapittel
Gawin, Agnieszka; Valla, Svein; Brautaset, Trygve. (2017) The XylS/Pm regulator/promoter system and its use in fundamental studies of bacterial gene expression, recombinant protein production and metabolic engineering. Microbial Biotechnology
Vitenskapelig oversiktsartikkel/review
Le, Simone Balzer; Heggset, Tonje Marita Bjerkan; Haugen, Tone; Nærdal, Ingemar; Brautaset, Trygve. (2017) 6-Phosphofructokinase and ribulose-5-phosphate 3-epimerase in methylotrophic Bacillus methanolicus ribulose monophosphate cycle. Applied Microbiology and Biotechnology
Vitenskapelig artikkel
Nærdal, Ingemar; Netzer, Roman; Irla, Marta; Krog, Anne; Heggset, Tonje Marita Bjerkan; Wendisch, Volker F.. (2017) L-lysine production by Bacillus methanolicus: Genome-based mutational analysis and L-lysine secretion engineering. Journal of Biotechnology
Vitenskapelig artikkel
Pfeifenschneider, Johannes; Brautaset, Trygve; Wendisch, Volker F.. (2017) Methanol as a carbon substrate in the bio-economy: metabolic engineering of aerobic methylotrophic bacteria for production of value-added chemicals. Biofuels, Bioproducts and Biorefining
Vitenskapelig oversiktsartikkel/review

2016

Carnicer, Marc; Vieira, Gilles; Brautaset, Trygve; Portais, Jean-Charles; Heux, Stéphanie. (2016) Quantitative metabolomics of the thermophilic methylotroph Bacillus methanolicus. Microbial Cell Factories
Vitenskapelig artikkel
Brautaset, Trygve; Åm, Heidrun; Aune, Marie Hjelmseth. (2016) Dragvoll og Gløshaugen trenger hverandre. Adressavisen
Kronikk
Brautaset, Trygve. (2016) Syntetisk biologi - muligheter og trusler. Biolog
Populærvitenskapelig artikkel
Wimark, Odd-Gunnar; Brautaset, Trygve. (2016) Report: Synthetic biology - biosafety and contribution to addressing societal challenges Chapter 1: Synthetic Biology: Science, Experimental Approaches and Applications in Biotechnology. GenØk – Senter for biosikkerhet, Forskningsparken i Breivika, Postboks 6418, 9294 Tromsø
Rapport
Irla, Marta; Heggset, Tonje Marita Bjerkan; Nærdal, Ingemar; Paul, Lidia; Haugen, Tone; Le, Simone Balzer. (2016) Genome-based genetic tool development for Bacillus methanolicus: Theta-and rolling circle-replicating plasmids for inducible gene expression and application to methanol-based cadaverine production. Frontiers in Microbiology
Vitenskapelig artikkel
Aasen, Inga Marie; Ertesvåg, Helga; Heggeset, Tonje Marita Bjerkan; Liu, Bin; Brautaset, Trygve; Vadstein, Olav. (2016) Thraustochytrids as production organisms for docosahexaenoic acid (DHA), squalene, and carotenoids. Applied Microbiology and Biotechnology
Vitenskapelig oversiktsartikkel/review
Liu, Bin; Ertesvåg, Helga; Aasen, Inga Marie; Vadstein, Olav; Brautaset, Trygve; Heggeset, Tonje Marita Bjerkan. (2016) Draft genome sequence of the docosahexaenoic acid producing thraustochytrid Aurantiochytrium sp. T66. Genomics Data
Vitenskapelig artikkel

2015

Almaas, Eivind; Brautaset, Trygve. (2015) Syntetisk biologi. Gyldendal Norsk Forlag A/S
Populærvitenskapelig kapittel/artikkel
Nærdal, Ingemar; Pfeifenschneider, Johannes; Brautaset, Trygve; Wendisch, Volker F.. (2015) Methanol-based cadaverine production by genetically engineered Bacillus methanolicus strains. Microbial Biotechnology
Vitenskapelig artikkel
Irla, Marta; Neshat, Armin; Brautaset, Trygve; Rückert, Christian; Kalinowski, Jörn; Wendisch, Volker F.. (2015) Transcriptome analysis of thermophilic methylotrophic Bacillus methanolicus MGA3 using RNA-sequencing provides detailed insights into its previously uncharted transcriptional landscape. BMC Genomics
Vitenskapelig artikkel
Müller, Jonas E.N.; Meyer, Fabian; Litsanov, Boris; Kiefer, Patrick; Potthoff, Eva; Heux, Stéphanie. (2015) Engineering Escherichia coli for methanol conversion. Metabolic Engineering
Vitenskapelig artikkel

2014

Heider, Sabine; Peters-Wendisch, Petra; Netzer, Roman; Stafsnes, Marit Hallvardsdotter; Brautaset, Trygve; Wendisch, Volker F.. (2014) Production and glucosylation of C50 and C40 carotenoids by metabolically engineered Corynebacterium glutamuicum. Applied Microbiology and Biotechnology
Vitenskapelig artikkel
Markert, Benno; Stolzenberger, Jessica; Brautaset, Trygve; Wendisch, Volker F.. (2014) Characterization of two transketolases encoded on the chromosome and the plasmid pBM19 of the facultative ribulose monophosphate cycle methylotroph Bacillus methanolicus. BMC Microbiology
Vitenskapelig artikkel
Müller, Jonas E.N.; Litsanov, Boris; Bortfeld-Miller, Miriam; Trachsel, Christian; Grossmann, Jonas; Brautaset, Trygve. (2014) Proteomic analysis of the thermophilic methylotroph Bacillus methanolicus MGA3. Proteomics
Vitenskapelig artikkel
Irla, Marta; Neshat, Armin; Winkler, Anika; Albersmeier, Andreas; Heggeset, Tonje Marita Bjerkan; Brautaset, Trygve. (2014) Complete genome sequence of Bacillus methanolicus MGA3, a thermotolerant amino acid producing methylotroph. Journal of Biotechnology
Vitenskapelig artikkel
Müller, Jonas E.N.; Heggeset, Tonje Marita Bjerkan; Wendisch, Volker F.; Vorholt, Julia A.; Brautaset, Trygve. (2014) Methylotrophy in the thermophilic Bacillus methanolicus, basic insights and application for commodity production from methanol. Applied Microbiology and Biotechnology
Vitenskapelig artikkel

2013

Kucharova, Veronika; Aakvik, Trine; Almaas, Eivind; Naas, Adrian Ertsås; Brautaset, Trygve; Valla, Svein. (2013) Non-Invasive Analysis of Recombinant mRNA Stability in Escherichia coli by a Combination of Transcriptional Inducer Wash-Out and qRT-PCR. PLOS ONE
Vitenskapelig artikkel
Tøndervik, Anne; Balzer, Simone; Haugen, Tone; Sletta, Håvard; Rode, Marit; Lindmo, Karine. (2013) High production of recombinant Norwegian salmonid alphavirus E1 and E2 proteins in Escherichia coli by fusion to secretion signal sequences and removal of hydrophobic domains. Biotechnology and Bioprocess Engineering
Vitenskapelig artikkel
Stolzenberger, J; Linder, SN; Persicke, M; Brautaset, Trygve; Wendisch, VF. (2013) Characterization of Fructose 1,6-Bisphosphatase and Sedoheptulose 1,7-Bisphosphatase from the Facultative Ribulose Monophosphate Cycle Methylotroph Bacillus methanolicus. Journal of Bacteriology
Vitenskapelig artikkel
Balzer, Simone; Kucharova, Veronika; Megerle, Judith; Lale, Rahmi; Brautaset, Trygve; Valla, Svein. (2013) A comparative analysis of the properties of regulated promoter systems commonly used for recombinant gene expression in Escherichia coli. Microbial Cell Factories
Vitenskapelig artikkel
Krog, Anne; Heggeset, Tonje Marita Bjerkan; Müller, Jonas E.N.; Kupper, Christiane E.; Schneider, Olha; Vorholt, Julia A.. (2013) Methylotrophic Bacillus methanolicus encodes two chromosomal and one plasmid born NAD+ dependent methanol dehydrogenase paralogs with different catalytic and biochemical properties. PLOS ONE
Vitenskapelig artikkel
Berg, Laila; Aakvik, Trine; Valla, Svein; Brautaset, Trygve. (2013) Combinatorial Mutagenesis and Selection to Understand and Improve Yeast Promoters. Biomedical Research
Vitenskapelig artikkel
Heggeset, Tonje Marita Bjerkan; Kucharova, Veronika; Nærdal, Ingemar; Valla, Svein; Sletta, Håvard; Ellingsen, Trond Erling. (2013) Combinatorial Mutagenesis and Selection of Improved Signal Sequences and Their Application for High-Level Production of Translocated Heterologous Proteins in Escherichia coli. Applied and Environmental Microbiology
Vitenskapelig artikkel
Kucharova, Veronika; Skancke, Jørgen; Brautaset, Trygve; Valla, Svein. (2013) Design and optimization of short DNA sequences that can be used as 5' fusion partners for high-level expression of heterologous genes in Escherichia coli. Applied and Environmental Microbiology
Vitenskapelig artikkel
Krog, Anne; Heggeset, Tonje Marita Bjerkan; Ellingsen, Trond Erling; Brautaset, Trygve. (2013) Functional Characterization of Key Enzymes involved in L-Glutamate Synthesis and Degradation in the Thermotolerant and Methylotrophic Bacterium Bacillus methanolicus. Applied and Environmental Microbiology
Vitenskapelig artikkel

2012

Berg, Laila; Kucharova, Veronika; Bakke, Ingrid; Valla, Svein; Brautaset, Trygve. (2012) Exploring the 5 '-UTR DNA region as a target for optimizing recombinant gene expression from the strong and inducible Pm promoter in Escherichia coli. Journal of Biotechnology
Vitenskapelig artikkel
Heggeset, Tonje Marita; Krog, Anne; Balzer, Simone; Wentzel, Alexander; Ellingsen, Trond Erling; Brautaset, Trygve. (2012) Genome Sequence of Thermotolerant Bacillus methanolicus: Features and Regulation Related to Methylotrophy and Production of L-Lysine and L-Glutamate from Methanol. Applied and Environmental Microbiology
Vitenskapelig artikkel

2011

Lale, Rahmi; Brautaset, Trygve; Valla, Svein. (2011) Broad-Host-Range Plasmid Vectors for Gene Expression in Bacteria. Springer Science+Business Media B.V.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
Nærdal, Ingemar; Netzer, Roman; Ellingsen, Trond Erling; Brautaset, Trygve. (2011) Analysis and Manipulation of Aspartate Pathway Genes for L-Lysine Overproduction from Methanol by Bacillus methanolicus. Applied and Environmental Microbiology
Vitenskapelig artikkel
Brautaset, Trygve; Ellingsen, Trond Erling. (2011) Lysine: Industrial Uses and Production. Elsevier
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
Lale, Rahmi; Berg, Laila; Stuttgen, Friederike; Netzer, Roman; Stafsnes, Marit Hallvardsdotter; Brautaset, Trygve. (2011) Continuous Control of the Flow in Biochemical Pathways through 5 ' Untranslated Region Sequence Modifications in mRNA Expressed from the Broad-Host-Range Promoter Pm. Applied and Environmental Microbiology
Vitenskapelig artikkel
Brautaset, Trygve; Sletta, Håvard; Degnes, Kristin Fløgstad; Sekurova, Olga; Bakke, Ingrid; Volokhan, Olga. (2011) New nystatin-related antifungal polyene macrolides with altered polyol region generated via biosynthetic engineering of Streptomyces noursei. Applied and Environmental Microbiology
Vitenskapelig artikkel

2010

Aune, Trond Erik Vee; Bakke, Ingrid; Drabløs, Finn; Lale, Rahmi; Brautaset, Trygve; Valla, Svein. (2010) Directed evolution of the transcription factor XylS for development of improved expression systems. Microbial Biotechnology
Vitenskapelig artikkel
Brautaset, Trygve; Jakobsen, Øyvind Mejdell; Degnes, Kristin F.; Netzer, Roman; Nærdal, Ingemar; Krog, Anne. (2010) Bacillus methanolicus pyruvate carboxylase and homoserine dehydrogenase I and II and their roles for L-lysine production from methanol at 50°C. Applied Microbiology and Biotechnology
Vitenskapelig artikkel
Netzer, Roman; Stafsnes, Marit Hallvardsdotter; Andreassen, Trygve; Goksøyr, Audun; Bruheim, Per; Brautaset, Trygve. (2010) Biosynthetic Pathway for g-Cyclic Sarcinaxanthin in Micrococcus luteus: Heterologous Expression and Evidence for Diverse and Multiple Catalytic Functions of C50 Carotenoid Cyclases. Journal of Bacteriology
Vitenskapelig artikkel

2009

Bakke, Ingrid; Berg, Laila; Aune, Trond Erik Vee; Brautaset, Trygve; Sletta, Håvard; Tøndervik, Anne. (2009) Random Mutagenesis of the Pm Promoter as a Powerful Strategy for Improvement of Recombinant-Gene Expression. Applied and Environmental Microbiology
Vitenskapelig artikkel
Brautaset, Trygve; Lale, Rahmi; Valla, Svein. (2009) Minireview - Positively regulated bacterial expression systems. Microbial Biotechnology
Vitenskapelig artikkel
Jakobsen, Øyvind Mejdell; Brautaset, Trygve; Degnes, Kristin F.; Heggeset, Tonje M.B.; Balzer, Simone; Flickinger, Michael C.. (2009) Overexpression of Wild-Type Aspartokinase Increases L-Lysine Production in the Thermotolerant Methylotrophic Bacterium Bacillus methanolicus. Applied and Environmental Microbiology
Vitenskapelig artikkel

2008

Brautaset, Trygve; Sletta, Håvard; Nedal, Aina; Borgos, Sven Even F.; Degnes, Kristin F.; Bakke, Ingrid. (2008) Improved Antifungal Polyene Macrolides via Engineering of the Nystatin Biosynthetic Genes in Streptomyces noursei. Chemistry and Biology
Vitenskapelig artikkel
Brautaset, Trygve. (2008) Improved antifungal polyene macrolides via engineering of the nystatin biosynthetic genes in Streptomyces noursei. Chemistry and Biology
Vitenskapelig artikkel

2007

Brautaset, Trygve; Jakobsen, Øyvind Mejdell; Josefsen, Kjell D.; Flickinger, Michael C.; Ellingsen, Trond Erling. (2007) Bacillus methanolicus: a candidate for industrial production of amino acids from methanol at 50°C. Applied Microbiology and Biotechnology
Vitenskapelig oversiktsartikkel/review
Sletta, Håvard; Tøndervik, Anne; Hakvåg, Sigrid; Nedal, Aina; Aune, Trond Erik Vee; Aune, Randi. (2007) The presence of N-terminal secretion signal sequences leads to strong stimulation of the total expression levels of three tested medically important proteins during high-cell-density cultivations of Escherichia coli. Applied and Environmental Microbiology
Vitenskapelig artikkel
Nedal, Aina; Sletta, Håvard; Brautaset, Trygve; Borgos, Sven Even F.; Sekurova, Olga; Ellingsen, Trond E.. (2007) Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455. Applied and Environmental Microbiology
Vitenskapelig artikkel

2006

Borgos, Sven Even F.; Sletta, Håvard; Fjærvik, Espen; Brautaset, Trygve; Ellingsen, Trond Erling; Gulliksen, Ole-Martin. (2006) Effect of glucose limitation and specific mutations in the module 5 enoyl reductase domains in the nystatin and amphotericin polyketide synthases on polyene macrolide biosynthesis. Archives of Microbiology
Vitenskapelig artikkel
Jakobsen, Øyvind Mejdell; Benichou, Aline; Flickinger, Michael C.; Valla, Svein; Ellingsen, Trond Erling; Brautaset, Trygve. (2006) Upregulated transcription of plasmid and chromosomal ribulose monophosphate pathway genes is critical for methanol assimilation rate and methanol tolerance in the methylotrophic bacterium Bacillus methanolicus. Journal of Bacteriology
Vitenskapelig artikkel

2005

Jakobsen, OM; Flickinger, Michael C.; Valla, Svein; Ellingsen, Trond Erling; Brautaset, Trygve. (2005) Plasmid-dependent methylotrophy and its significance for the Biology of thermotolerant bacterium Bacillus methanolicus. Journal of Biotechnology
Sammendrag/abstract

2004

Sletta, Håvard; Nedal, Aina; Aune, Trond Erik Vee; Hellebust, H.; Hakvåg, Sigrid; Aune, R.. (2004) Broad-host-range plasmid pJB658 can be used for industrial-level production of a secreted host-toxic single-chain antibody fragment in Escherichia coli. Applied and Environmental Microbiology
Vitenskapelig artikkel
Brautaset, Trygve; Jakobsen, OM; Flickinger, Michael C.; Valla, Svein; Ellingsen, Trond Erling. (2004) Plasmid-dependent methylotrophy in thermotolerant Bacillus methanolicus. Journal of Bacteriology
Vitenskapelig artikkel
Sekurova, Olga; Brautaset, Trygve; Sletta, Håvard; Borgos, Sven Even F.; Jakobsen, OM; Ellingsen, Trond Erling. (2004) In vivo analysis of the regulatory genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455 reveals their differential control over antibiotic biosynthesis. Journal of Bacteriology
Vitenskapelig artikkel

2003

Brautaset, Trygve; Williams, Mark; Dillingham, Richard; Flickinger, Michael. (2003) The role of the Bacillus methanolicus citrate synthase II gene, citY, in regulating the secretion of glutamate in L-lysine secreting mutants. Applied and Environmental Microbiology
Vitenskapelig artikkel
Brautaset, Trygve; Borgos, Sven Even F.; Sletta, Håvard; Ellingsen, Trond Erling; Zotchev, Sergey. (2003) Site-specific mutagenesis and domain substitutions in the loading module of the nystatin polyketide synthase, and their effects on nystatin synthesis in Streptomyces noursei. Journal of Biological Chemistry
Vitenskapelig artikkel
Brautaset, Trygve; Williams, Mark D.; Dillingham, Richard D.; Kaufmann, Christine; Bennaars, Assumpta; Crabbe, Edward. (2003) Role of the Bacillus methanolicus citrate synthase II gene, citY, in regulating the secretion of glutamate in L-lysine-secreting mutants. Applied and Environmental Microbiology
Vitenskapelig artikkel
Brautaset, Trygve; Borgos, Sven Even F.; Sletta, Håvard; Ellingsen, Trond E.; Zotchev, Sergey. (2003) Site-specific mutagenesis and domain substitutions in the loading module of the nystatin polyketide synthase, and their effects on nystatin biosynthesis in Streptomyces noursei. Journal of Biological Chemistry
Vitenskapelig artikkel

2002

Brautaset, Trygve; Bruheim, Per; Sletta, Håvard; Hagen, Lars; Ellingsen, Trond E.; Strøm, Arne Reidar. (2002) Hexaene derivatives of nystatin produced as a result of an induced rearrangement within the nysC polyketide synthase gene in S. noursei ATCC 11455. Chemistry and Biology
Vitenskapelig artikkel

2001

Brautaset, Trygve; Zotchev, Sergey. (2001) Cloning and sequencing of a polyene antibiotic biosynthetic gene cluster. QIAGEN Newsletter
Vitenskapelig artikkel

2000

Brautaset, Trygve; Petersen, Steffen B.; Valla, Svein. (2000) In vitro determined kinetic properties of mutant phosphoglucomutases and their effects on sugar catabolism in Escherichia coli. Metabolic Engineering
Vitenskapelig artikkel
Winther-Larsen, Hanne C.; Josefsen, Kjell D.; Brautaset, Trygve; Valla, Svein. (2000) Parameters affecting gene expression from the Pm promoter in gram-negative bacteria. Metabolic Engineering
Vitenskapelig artikkel
Winther-Larsen, Hanne C.; Blatny, Janet M.; Valand, Bjørnar; Brautaset, Trygve; Valla, Svein. (2000) Pm promoter expression mutants and their use in broad-host-range RK2 plasmid vectors. Metabolic Engineering
Vitenskapelig artikkel
Brautaset, Trygve; Sekurova, Olga; Sletta, Håvard; Ellingsen, Trond E.; Strøm, Arne Reidar; Valla, Svein. (2000) Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455 : analysis of the gene cluster and deduction of the biosynthetic pathway. Chemistry and Biology
Vitenskapelig artikkel

1999

Zotchev, Sergey; Brautaset, Trygve. (1999) Genetic manipulations of antibiotic-producing bacteria - an approach to creating new antibiotics. NBS-nytt
Vitenskapelig artikkel
Zotchev, Sergey; Brautaset, Trygve. (1999) Genetic manipulations of antibiotic-producing bacteria- an approach to creating new antibiotics. NBS-nytt
Vitenskapelig artikkel
Brautaset, Trygve. (1999) Enzyme Engineering. NBS-nytt
Vitenskapelig artikkel

1998

Brautaset, Trygve; Petersen, Steffen; Valla, Svein. (1998) An Experimental study on carbon flow in Escherichia coli as a function of kinetic properties and expression levels of the enzyme phosphoglucomutase. Biotechnology and Bioengineering
Vitenskapelig artikkel
Brautaset, Trygve. (1998) Phosphoglucomutase and its mutant derivatives as models for studies of carbon flow in Escherichia coli. NTNU Trondheim Norwegian University of Science and Technology
Doktorgradsavhandling

1997

Blatny, Janet Martha; Brautaset, Trygve; Winther-Larsen, Hanne C.; Haugan, Kåre; Valla, Svein. (1997) Construction and use of a versatile set of broad-host-range cloning an d expression vectors based on the RK2 replicon. Applied and Environmental Microbiology
Vitenskapelig artikkel
Blatny, Janet Martha; Brautaset, Trygve; Winther-Larsen, Hanne C.; Karunakaran, Ponniah; Valla, Svein. (1997) Improved broad-host-range RK2 vectors useful for high and low regulated gene expression levels in gram-negative bacteria. Plasmid
Vitenskapelig artikkel
Blatny, Janet Martha; Karunakaran, Ponniah; Brautaset, Trygve; Knutsen, Torill Irene; Winther-Larsen, Hanne C.; Valla, Svein. (1997) New RK2 vectors useful in biotechnology and for analyses of RK2 replication and copy number control. Plasmid
Vitenskapelig artikkel
Blatny, Janet Martha; Brautaset, Trygve; Winther-Larsen, Hanne C.; Haugan, Kåre; Valla, Svein. (1997) Construction and use of a versatile set of broad-host-range cloning an d expression vectors based on the RK2 replicon. Applied and Environmental Microbiology
Vitenskapelig artikkel
Brautaset, Trygve. (1997) Construction and use of a versatile set of broad-host-range cloning and expression vectors based on the RK2 replicon. Applied and Environmental Microbiology
Vitenskapelig artikkel

1996

Valla, Svein; Brautaset, Trygve. (1996) Metabolsk ingeniørkunst; Hva er det og hva kan det brukes til?. Kjemi
Vitenskapelig artikkel

1995

Baptista, Antonio; Brautaset, Trygve; Drabløs, Finn; Martel, Paulo; Valla, Svein; Petersen, Steffen-B.. (1995) Electrostatic studies of carbohydrate active enzymes. Carbohydrate bioengineering : proceedings of an international conference
Vitenskapelig artikkel

1994

Brautaset, Trygve; Standal, Rune; Fjærvik, Espen; Valla, Svein. (1994) Nucleotide sequence and expression analysis of the Acetobacter xylinum phosphoglucomutase gene. Microbiology
Vitenskapelig artikkel

Tidsskriftspublikasjoner

Irla, Marta Katarzyna; Nærdal, Ingemar; Virant, David; Brautaset, Trygve; Busche, Tobias; Goranovič, Dušan. (2025) Systems-level analysis provides insights on methanol-based production of L-glutamate and its decarboxylation product γ-aminobutyric acid by Bacillus methanolicus. Metabolic Engineering
Vitenskapelig artikkel
Gamlund, Espen; Barra, Mathias; Brautaset, Trygve. (2024) Surrogati bør ikke straffes. Morgenbladet
Leserinnlegg
Perez Garcia, Fernando; Fernandes de Brito, Luciana; Bakken, Thea Isabel; Brautaset, Trygve. (2024) Riboflavin overproduction from diverse feedstocks with engineered Corynebacterium glutamicum. Biofabrication
Vitenskapelig artikkel
Bastem, Gülsüm Merve; Sayar, Nihat Alpagu; Fernandes de Brito, Luciana; Brautaset, Trygve; Virant, David; Sariyar Akbulut, Berna. (2024) Development of a novel process towards an L-malate biorefinery using methanol as feedstock. Chemical engineering research & design
Vitenskapelig artikkel
Klein, Vivien Jessica; Troøyen, Susanne Hansen; Fernandes de Brito, Luciana; Courtade, Gaston; Brautaset, Trygve; Irla, Marta Katarzyna. (2024) Identification and characterization of a novel formaldehyde dehydrogenase in Bacillus subtilis. Applied and Environmental Microbiology
Vitenskapelig artikkel
Klein, Vivien Jessica; Fernandes de Brito, Luciana; Perez Garcia, Fernando; Brautaset, Trygve; Irla, Marta Katarzyna. (2023) Metabolic engineering of thermophilic Bacillus methanolicus for riboflavin overproduction from methanol. Microbial Biotechnology
Vitenskapelig artikkel
Bratlie, Sigrid; Alsheikh, Muath K; Brautaset, Trygve; Gamlund, Espen; Holst-Jensen, Arne; Tøndel, Camilla. (2023) Mer faglighet fra naturbevegelsen, takk. Klassekampen
Leserinnlegg
Bratlie, Sigrid; Holst-Jensen, Arne; Alsheikh, Muath K; Brautaset, Trygve; Gamlund, Espen; Tøndel, Camilla. (2023) På tide å åpne for genteknologi i norsk matproduksjon. Nationen
Kronikk
Bratlie, Sigrid; Tøndel, Camilla; Alsheikh, Muath K; Brautaset, Trygve; Gamlund, Espen; Holst-Jensen, Arne. (2023) GMO-regler må ikke få stoppe utviklingen av avanserte terapier. Dagens medisin
Kronikk
Gamlund, Espen; Alsheikh, Muath K; Bratlie, Sigrid; Brautaset, Trygve; Holst-Jensen, Arne; Tøndel, Camilla. (2023) Uetisk å la være å satse på genteknologi. Dagsavisen
Kronikk
Perez-Garcia, Fernando; Klein, Vivien Jessica; Fernandes de Brito, Luciana; Brautaset, Trygve. (2022) From Brown Seaweed to a Sustainable Microbial Feedstock for the Production of Riboflavin. Frontiers in Bioengineering and Biotechnology
Vitenskapelig artikkel
Klein, Vivien Jessica; Irla, Marta Katarzyna; Gil Lopez, Marina; Brautaset, Trygve; Fernandes de Brito, Luciana. (2022) Unravelling Formaldehyde Metabolism in Bacteria: Road towards Synthetic Methylotrophy. Microorganisms
Vitenskapelig oversiktsartikkel/review
Wendisch, Volker F.; Kosec, Gregor; Heux, Stéphanie; Brautaset, Trygve. (2021) Aerobic Utilization of Methanol for Microbial Growth and Production. Advances in Biochemical Engineering, Biotechnology
Vitenskapelig oversiktsartikkel/review
Irla, Marta Katarzyna; Hakvåg, Sigrid; Brautaset, Trygve. (2021) Developing a riboswitch-mediated regulatory system for metabolic flux control in thermophilic bacillus methanolicus. International Journal of Molecular Sciences
Vitenskapelig artikkel
Fernandes de Brito, Luciana; Irla, Marta Katarzyna; Nærdal, Ingemar; Le, Simone Balzer; Baudoin, Delepine; Heux, Stéphanie. (2021) Evaluation of Heterologous Biosynthetic Pathways for Methanol-Based 5-Aminovalerate Production by Thermophilic Bacillus methanolicus. Frontiers in Bioengineering and Biotechnology
Vitenskapelig artikkel
Brautaset, Trygve. (2021) Genteknologisk vaksine gir nytt håp. Genialt - Tidsskrift fra Bioteknologirådet
Populærvitenskapelig artikkel
Khider, May Laura Kilano; Brautaset, Trygve; Irla, Marta Katarzyna. (2021) Methane monooxygenases: central enzymes in methanotrophy with promising biotechnological applications. World Journal of Microbiology & Biotechnology
Vitenskapelig artikkel
Brautaset, Trygve; Jonassen, Inge; Bösl, Korbinian; Norunn K, Torheim. (2020) På tide å sette av fem prosent av prosjektmidlene til datahåndtering? . Khrono.no
Populærvitenskapelig artikkel
Drejer, Eivind Bøe; Chan, Dennis; Haupka, Carsten; Wendisch, Volker F.; Brautaset, Trygve; Irla, Marta Katarzyna. (2020) Methanol-based acetoin production by genetically engineered Bacillus methanolicus. Green Chemistry
Vitenskapelig artikkel
Gawin, Agnieszka Maria; Tietze, Lisa; Aarstad, Olav Andreas; Aachmann, Finn Lillelund; Brautaset, Trygve; Ertesvåg, Helga. (2020) Functional characterization of three Azotobacter chroococcum alginate-modifying enzymes related to the Azotobacter vinelandii AlgE mannuronan C-5-epimerase family. Scientific Reports
Vitenskapelig artikkel
Irla, Marta Katarzyna; Drejer, Eivind Bøe; Brautaset, Trygve; Hakvåg, Sigrid. (2020) Establishment of a functional system for recombinant production of secreted proteins at 50 °C in the thermophilic Bacillus methanolicus. Microbial Cell Factories
Vitenskapelig artikkel
Pfeifenschneider, Johannes; Markert, Benno; Stolzenberger, Jessica; Brautaset, Trygve; Wendisch, Volker F.. (2020) Transaldolase in Bacillus methanolicus: biochemical characterization and biological role in ribulose monophosphate cycle. BMC Microbiology
Vitenskapelig artikkel
Hakvåg, Sigrid; Nærdal, Ingemar; Heggeset, Tonje Marita Bjerkan; Kristiansen, Kåre Andre; Aasen, Inga Marie; Brautaset, Trygve. (2020) Production of Value-Added Chemicals by Bacillus methanolicus Strains Cultivated on Mannitol and Extracts of Seaweed Saccharina latissima at 50C. Frontiers in Microbiology
Vitenskapelig artikkel
Allahgholi, Leila; Sardari, Roya R.R.; Hakvåg, Sigrid; Ara, Kazi Z.G.; Kristjansdottir, Thordis Anna; Aasen, Inga Marie. (2020) Composition analysis and minimal treatments to solubilize polysaccharides from the brown seaweed Laminaria digitata for microbial growth of thermophiles. Journal of Applied Phycology
Vitenskapelig artikkel
Hans, Sebastian; Ulmer, Christian; Narayanan, Harini; Brautaset, Trygve; Krausch, Niels; Neubauer, Peter. (2020) Monitoring Parallel Robotic Cultivations with Online Multivariate Analysis. Processes
Vitenskapelig artikkel
Gawin, Agnieszka Maria; Ertesvåg, Helga; Hansen, Sine Alise Hartvigsen; Malmo, Jostein; Brautaset, Trygve. (2020) Translational regulation of periplasmic folding assistants and proteases as a valuable strategy to improve production of translocated recombinant proteins in Escherichia coli. BMC Biotechnology
Vitenskapelig artikkel
Schultenkamper, Kerstin; Fernandes de Brito, Luciana; Lopez, Marina Gil; Brautaset, Trygve; Wendisch, Volker F.. (2019) Establishment and application of CRISPR interference to affect sporulation, hydrogen peroxide detoxification, and mannitol catabolism in the methylotrophic thermophile Bacillus methanolicus. Applied Microbiology and Biotechnology
Vitenskapelig artikkel
Gawin, Agnieszka; Peebo, Karl; Sebastian, Hans; Ertesvåg, Helga; Irla, Marta Katarzyna; Neubauer, Peter. (2019) Construction and characterization of broad-host-range reporter plasmid suitable for on-line analysis of bacterial host responses related to recombinant protein production. Microbial Cell Factories
Vitenskapelig artikkel
Nærdal, Ingemar; Pfeifenschneider, Johannes; Brautaset, Trygve; Wendisch, Volker F.. (2019) Corrigendum Methanol-based cadaverine production by genetically engineered Bacillus methanolicus strains. Microbial Biotechnology
Errata
Brautaset, Trygve; Valla, Svein. (2019) Special Issue: Recombinant Protein Expression in Microorganisms. Microorganisms
Short communication
Irla, Marta Katarzyna; Heggeset, Tonje Marita Bjerkan; Nærdal, Ingemar; Paul, Lidia; Haugen, Tone; Le, Simone Balzer. (2019) Corrigendum: Genome-Based Genetic Tool Development for Bacillus methanolicus: Theta- and Rolling Circle-Replicating Plasmids for Inducible Gene Expression and Application to Methanol-Based Cadaverine Production. Frontiers in Microbiology
Errata
Görbitz, Carl Henrik; Jakobsen, Kjetill Sigurd; Sandve, Simen Rød; Goksøyr, Anders; Brautaset, Trygve; Jørgensen, Trond Ø.. (2019) Den sjette masseutryddelse og Jordens DNA. Aftenposten (morgenutg. : trykt utg.)
Kronikk
Schultenkämper, Kerstin; Fernandes de Brito, Luciana; Gil López, Marina; Brautaset, Trygve; Wendisch, Volker F.. (2019) Establishment and application of CRISPR interference to affect sporulation, hydrogen peroxide detoxification, and mannitol catabolism in the methylotrophic thermophile Bacillus methanolicus. Applied Microbiology and Biotechnology
Vitenskapelig artikkel
Drejer, Eivind Bøe; Hakvåg, Sigrid; Irla, Marta Katarzyna; Brautaset, Trygve. (2018) Genetic Tools and Techniques for Recombinant Expression in Thermophilic Bacillaceae. Microorganisms
Vitenskapelig oversiktsartikkel/review
Irla, Marta; Nærdal, Ingemar; Brautaset, Trygve; Wendisch, Volker F.. (2017) Methanol-based γ-aminobutyric acid (GABA) production by genetically engineered Bacillus methanolicus strains. Industrial crops and products (Print)
Vitenskapelig artikkel
Courtade, Gaston; Le, Simone Balzer; Sætrom, Gerd Inger; Brautaset, Trygve; Aachmann, Finn Lillelund. (2017) A novel expression system for lytic polysaccharide monooxygenases. Carbohydrate Research
Vitenskapelig artikkel
Gawin, Agnieszka; Valla, Svein; Brautaset, Trygve. (2017) The XylS/Pm regulator/promoter system and its use in fundamental studies of bacterial gene expression, recombinant protein production and metabolic engineering. Microbial Biotechnology
Vitenskapelig oversiktsartikkel/review
Le, Simone Balzer; Heggset, Tonje Marita Bjerkan; Haugen, Tone; Nærdal, Ingemar; Brautaset, Trygve. (2017) 6-Phosphofructokinase and ribulose-5-phosphate 3-epimerase in methylotrophic Bacillus methanolicus ribulose monophosphate cycle. Applied Microbiology and Biotechnology
Vitenskapelig artikkel
Nærdal, Ingemar; Netzer, Roman; Irla, Marta; Krog, Anne; Heggset, Tonje Marita Bjerkan; Wendisch, Volker F.. (2017) L-lysine production by Bacillus methanolicus: Genome-based mutational analysis and L-lysine secretion engineering. Journal of Biotechnology
Vitenskapelig artikkel
Pfeifenschneider, Johannes; Brautaset, Trygve; Wendisch, Volker F.. (2017) Methanol as a carbon substrate in the bio-economy: metabolic engineering of aerobic methylotrophic bacteria for production of value-added chemicals. Biofuels, Bioproducts and Biorefining
Vitenskapelig oversiktsartikkel/review
Carnicer, Marc; Vieira, Gilles; Brautaset, Trygve; Portais, Jean-Charles; Heux, Stéphanie. (2016) Quantitative metabolomics of the thermophilic methylotroph Bacillus methanolicus. Microbial Cell Factories
Vitenskapelig artikkel
Brautaset, Trygve; Åm, Heidrun; Aune, Marie Hjelmseth. (2016) Dragvoll og Gløshaugen trenger hverandre. Adressavisen
Kronikk
Brautaset, Trygve. (2016) Syntetisk biologi - muligheter og trusler. Biolog
Populærvitenskapelig artikkel
Irla, Marta; Heggset, Tonje Marita Bjerkan; Nærdal, Ingemar; Paul, Lidia; Haugen, Tone; Le, Simone Balzer. (2016) Genome-based genetic tool development for Bacillus methanolicus: Theta-and rolling circle-replicating plasmids for inducible gene expression and application to methanol-based cadaverine production. Frontiers in Microbiology
Vitenskapelig artikkel
Aasen, Inga Marie; Ertesvåg, Helga; Heggeset, Tonje Marita Bjerkan; Liu, Bin; Brautaset, Trygve; Vadstein, Olav. (2016) Thraustochytrids as production organisms for docosahexaenoic acid (DHA), squalene, and carotenoids. Applied Microbiology and Biotechnology
Vitenskapelig oversiktsartikkel/review
Liu, Bin; Ertesvåg, Helga; Aasen, Inga Marie; Vadstein, Olav; Brautaset, Trygve; Heggeset, Tonje Marita Bjerkan. (2016) Draft genome sequence of the docosahexaenoic acid producing thraustochytrid Aurantiochytrium sp. T66. Genomics Data
Vitenskapelig artikkel
Nærdal, Ingemar; Pfeifenschneider, Johannes; Brautaset, Trygve; Wendisch, Volker F.. (2015) Methanol-based cadaverine production by genetically engineered Bacillus methanolicus strains. Microbial Biotechnology
Vitenskapelig artikkel
Irla, Marta; Neshat, Armin; Brautaset, Trygve; Rückert, Christian; Kalinowski, Jörn; Wendisch, Volker F.. (2015) Transcriptome analysis of thermophilic methylotrophic Bacillus methanolicus MGA3 using RNA-sequencing provides detailed insights into its previously uncharted transcriptional landscape. BMC Genomics
Vitenskapelig artikkel
Müller, Jonas E.N.; Meyer, Fabian; Litsanov, Boris; Kiefer, Patrick; Potthoff, Eva; Heux, Stéphanie. (2015) Engineering Escherichia coli for methanol conversion. Metabolic Engineering
Vitenskapelig artikkel
Heider, Sabine; Peters-Wendisch, Petra; Netzer, Roman; Stafsnes, Marit Hallvardsdotter; Brautaset, Trygve; Wendisch, Volker F.. (2014) Production and glucosylation of C50 and C40 carotenoids by metabolically engineered Corynebacterium glutamuicum. Applied Microbiology and Biotechnology
Vitenskapelig artikkel
Markert, Benno; Stolzenberger, Jessica; Brautaset, Trygve; Wendisch, Volker F.. (2014) Characterization of two transketolases encoded on the chromosome and the plasmid pBM19 of the facultative ribulose monophosphate cycle methylotroph Bacillus methanolicus. BMC Microbiology
Vitenskapelig artikkel
Müller, Jonas E.N.; Litsanov, Boris; Bortfeld-Miller, Miriam; Trachsel, Christian; Grossmann, Jonas; Brautaset, Trygve. (2014) Proteomic analysis of the thermophilic methylotroph Bacillus methanolicus MGA3. Proteomics
Vitenskapelig artikkel
Irla, Marta; Neshat, Armin; Winkler, Anika; Albersmeier, Andreas; Heggeset, Tonje Marita Bjerkan; Brautaset, Trygve. (2014) Complete genome sequence of Bacillus methanolicus MGA3, a thermotolerant amino acid producing methylotroph. Journal of Biotechnology
Vitenskapelig artikkel
Müller, Jonas E.N.; Heggeset, Tonje Marita Bjerkan; Wendisch, Volker F.; Vorholt, Julia A.; Brautaset, Trygve. (2014) Methylotrophy in the thermophilic Bacillus methanolicus, basic insights and application for commodity production from methanol. Applied Microbiology and Biotechnology
Vitenskapelig artikkel
Kucharova, Veronika; Aakvik, Trine; Almaas, Eivind; Naas, Adrian Ertsås; Brautaset, Trygve; Valla, Svein. (2013) Non-Invasive Analysis of Recombinant mRNA Stability in Escherichia coli by a Combination of Transcriptional Inducer Wash-Out and qRT-PCR. PLOS ONE
Vitenskapelig artikkel
Tøndervik, Anne; Balzer, Simone; Haugen, Tone; Sletta, Håvard; Rode, Marit; Lindmo, Karine. (2013) High production of recombinant Norwegian salmonid alphavirus E1 and E2 proteins in Escherichia coli by fusion to secretion signal sequences and removal of hydrophobic domains. Biotechnology and Bioprocess Engineering
Vitenskapelig artikkel
Stolzenberger, J; Linder, SN; Persicke, M; Brautaset, Trygve; Wendisch, VF. (2013) Characterization of Fructose 1,6-Bisphosphatase and Sedoheptulose 1,7-Bisphosphatase from the Facultative Ribulose Monophosphate Cycle Methylotroph Bacillus methanolicus. Journal of Bacteriology
Vitenskapelig artikkel
Balzer, Simone; Kucharova, Veronika; Megerle, Judith; Lale, Rahmi; Brautaset, Trygve; Valla, Svein. (2013) A comparative analysis of the properties of regulated promoter systems commonly used for recombinant gene expression in Escherichia coli. Microbial Cell Factories
Vitenskapelig artikkel
Krog, Anne; Heggeset, Tonje Marita Bjerkan; Müller, Jonas E.N.; Kupper, Christiane E.; Schneider, Olha; Vorholt, Julia A.. (2013) Methylotrophic Bacillus methanolicus encodes two chromosomal and one plasmid born NAD+ dependent methanol dehydrogenase paralogs with different catalytic and biochemical properties. PLOS ONE
Vitenskapelig artikkel
Berg, Laila; Aakvik, Trine; Valla, Svein; Brautaset, Trygve. (2013) Combinatorial Mutagenesis and Selection to Understand and Improve Yeast Promoters. Biomedical Research
Vitenskapelig artikkel
Heggeset, Tonje Marita Bjerkan; Kucharova, Veronika; Nærdal, Ingemar; Valla, Svein; Sletta, Håvard; Ellingsen, Trond Erling. (2013) Combinatorial Mutagenesis and Selection of Improved Signal Sequences and Their Application for High-Level Production of Translocated Heterologous Proteins in Escherichia coli. Applied and Environmental Microbiology
Vitenskapelig artikkel
Kucharova, Veronika; Skancke, Jørgen; Brautaset, Trygve; Valla, Svein. (2013) Design and optimization of short DNA sequences that can be used as 5' fusion partners for high-level expression of heterologous genes in Escherichia coli. Applied and Environmental Microbiology
Vitenskapelig artikkel
Krog, Anne; Heggeset, Tonje Marita Bjerkan; Ellingsen, Trond Erling; Brautaset, Trygve. (2013) Functional Characterization of Key Enzymes involved in L-Glutamate Synthesis and Degradation in the Thermotolerant and Methylotrophic Bacterium Bacillus methanolicus. Applied and Environmental Microbiology
Vitenskapelig artikkel
Berg, Laila; Kucharova, Veronika; Bakke, Ingrid; Valla, Svein; Brautaset, Trygve. (2012) Exploring the 5 '-UTR DNA region as a target for optimizing recombinant gene expression from the strong and inducible Pm promoter in Escherichia coli. Journal of Biotechnology
Vitenskapelig artikkel
Heggeset, Tonje Marita; Krog, Anne; Balzer, Simone; Wentzel, Alexander; Ellingsen, Trond Erling; Brautaset, Trygve. (2012) Genome Sequence of Thermotolerant Bacillus methanolicus: Features and Regulation Related to Methylotrophy and Production of L-Lysine and L-Glutamate from Methanol. Applied and Environmental Microbiology
Vitenskapelig artikkel
Nærdal, Ingemar; Netzer, Roman; Ellingsen, Trond Erling; Brautaset, Trygve. (2011) Analysis and Manipulation of Aspartate Pathway Genes for L-Lysine Overproduction from Methanol by Bacillus methanolicus. Applied and Environmental Microbiology
Vitenskapelig artikkel
Lale, Rahmi; Berg, Laila; Stuttgen, Friederike; Netzer, Roman; Stafsnes, Marit Hallvardsdotter; Brautaset, Trygve. (2011) Continuous Control of the Flow in Biochemical Pathways through 5 ' Untranslated Region Sequence Modifications in mRNA Expressed from the Broad-Host-Range Promoter Pm. Applied and Environmental Microbiology
Vitenskapelig artikkel
Brautaset, Trygve; Sletta, Håvard; Degnes, Kristin Fløgstad; Sekurova, Olga; Bakke, Ingrid; Volokhan, Olga. (2011) New nystatin-related antifungal polyene macrolides with altered polyol region generated via biosynthetic engineering of Streptomyces noursei. Applied and Environmental Microbiology
Vitenskapelig artikkel
Aune, Trond Erik Vee; Bakke, Ingrid; Drabløs, Finn; Lale, Rahmi; Brautaset, Trygve; Valla, Svein. (2010) Directed evolution of the transcription factor XylS for development of improved expression systems. Microbial Biotechnology
Vitenskapelig artikkel
Brautaset, Trygve; Jakobsen, Øyvind Mejdell; Degnes, Kristin F.; Netzer, Roman; Nærdal, Ingemar; Krog, Anne. (2010) Bacillus methanolicus pyruvate carboxylase and homoserine dehydrogenase I and II and their roles for L-lysine production from methanol at 50°C. Applied Microbiology and Biotechnology
Vitenskapelig artikkel
Netzer, Roman; Stafsnes, Marit Hallvardsdotter; Andreassen, Trygve; Goksøyr, Audun; Bruheim, Per; Brautaset, Trygve. (2010) Biosynthetic Pathway for g-Cyclic Sarcinaxanthin in Micrococcus luteus: Heterologous Expression and Evidence for Diverse and Multiple Catalytic Functions of C50 Carotenoid Cyclases. Journal of Bacteriology
Vitenskapelig artikkel
Bakke, Ingrid; Berg, Laila; Aune, Trond Erik Vee; Brautaset, Trygve; Sletta, Håvard; Tøndervik, Anne. (2009) Random Mutagenesis of the Pm Promoter as a Powerful Strategy for Improvement of Recombinant-Gene Expression. Applied and Environmental Microbiology
Vitenskapelig artikkel
Brautaset, Trygve; Lale, Rahmi; Valla, Svein. (2009) Minireview - Positively regulated bacterial expression systems. Microbial Biotechnology
Vitenskapelig artikkel
Jakobsen, Øyvind Mejdell; Brautaset, Trygve; Degnes, Kristin F.; Heggeset, Tonje M.B.; Balzer, Simone; Flickinger, Michael C.. (2009) Overexpression of Wild-Type Aspartokinase Increases L-Lysine Production in the Thermotolerant Methylotrophic Bacterium Bacillus methanolicus. Applied and Environmental Microbiology
Vitenskapelig artikkel
Brautaset, Trygve; Sletta, Håvard; Nedal, Aina; Borgos, Sven Even F.; Degnes, Kristin F.; Bakke, Ingrid. (2008) Improved Antifungal Polyene Macrolides via Engineering of the Nystatin Biosynthetic Genes in Streptomyces noursei. Chemistry and Biology
Vitenskapelig artikkel
Brautaset, Trygve. (2008) Improved antifungal polyene macrolides via engineering of the nystatin biosynthetic genes in Streptomyces noursei. Chemistry and Biology
Vitenskapelig artikkel
Brautaset, Trygve; Jakobsen, Øyvind Mejdell; Josefsen, Kjell D.; Flickinger, Michael C.; Ellingsen, Trond Erling. (2007) Bacillus methanolicus: a candidate for industrial production of amino acids from methanol at 50°C. Applied Microbiology and Biotechnology
Vitenskapelig oversiktsartikkel/review
Sletta, Håvard; Tøndervik, Anne; Hakvåg, Sigrid; Nedal, Aina; Aune, Trond Erik Vee; Aune, Randi. (2007) The presence of N-terminal secretion signal sequences leads to strong stimulation of the total expression levels of three tested medically important proteins during high-cell-density cultivations of Escherichia coli. Applied and Environmental Microbiology
Vitenskapelig artikkel
Nedal, Aina; Sletta, Håvard; Brautaset, Trygve; Borgos, Sven Even F.; Sekurova, Olga; Ellingsen, Trond E.. (2007) Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455. Applied and Environmental Microbiology
Vitenskapelig artikkel
Borgos, Sven Even F.; Sletta, Håvard; Fjærvik, Espen; Brautaset, Trygve; Ellingsen, Trond Erling; Gulliksen, Ole-Martin. (2006) Effect of glucose limitation and specific mutations in the module 5 enoyl reductase domains in the nystatin and amphotericin polyketide synthases on polyene macrolide biosynthesis. Archives of Microbiology
Vitenskapelig artikkel
Jakobsen, Øyvind Mejdell; Benichou, Aline; Flickinger, Michael C.; Valla, Svein; Ellingsen, Trond Erling; Brautaset, Trygve. (2006) Upregulated transcription of plasmid and chromosomal ribulose monophosphate pathway genes is critical for methanol assimilation rate and methanol tolerance in the methylotrophic bacterium Bacillus methanolicus. Journal of Bacteriology
Vitenskapelig artikkel
Jakobsen, OM; Flickinger, Michael C.; Valla, Svein; Ellingsen, Trond Erling; Brautaset, Trygve. (2005) Plasmid-dependent methylotrophy and its significance for the Biology of thermotolerant bacterium Bacillus methanolicus. Journal of Biotechnology
Sammendrag/abstract
Sletta, Håvard; Nedal, Aina; Aune, Trond Erik Vee; Hellebust, H.; Hakvåg, Sigrid; Aune, R.. (2004) Broad-host-range plasmid pJB658 can be used for industrial-level production of a secreted host-toxic single-chain antibody fragment in Escherichia coli. Applied and Environmental Microbiology
Vitenskapelig artikkel
Brautaset, Trygve; Jakobsen, OM; Flickinger, Michael C.; Valla, Svein; Ellingsen, Trond Erling. (2004) Plasmid-dependent methylotrophy in thermotolerant Bacillus methanolicus. Journal of Bacteriology
Vitenskapelig artikkel
Sekurova, Olga; Brautaset, Trygve; Sletta, Håvard; Borgos, Sven Even F.; Jakobsen, OM; Ellingsen, Trond Erling. (2004) In vivo analysis of the regulatory genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455 reveals their differential control over antibiotic biosynthesis. Journal of Bacteriology
Vitenskapelig artikkel
Brautaset, Trygve; Williams, Mark; Dillingham, Richard; Flickinger, Michael. (2003) The role of the Bacillus methanolicus citrate synthase II gene, citY, in regulating the secretion of glutamate in L-lysine secreting mutants. Applied and Environmental Microbiology
Vitenskapelig artikkel
Brautaset, Trygve; Borgos, Sven Even F.; Sletta, Håvard; Ellingsen, Trond Erling; Zotchev, Sergey. (2003) Site-specific mutagenesis and domain substitutions in the loading module of the nystatin polyketide synthase, and their effects on nystatin synthesis in Streptomyces noursei. Journal of Biological Chemistry
Vitenskapelig artikkel
Brautaset, Trygve; Williams, Mark D.; Dillingham, Richard D.; Kaufmann, Christine; Bennaars, Assumpta; Crabbe, Edward. (2003) Role of the Bacillus methanolicus citrate synthase II gene, citY, in regulating the secretion of glutamate in L-lysine-secreting mutants. Applied and Environmental Microbiology
Vitenskapelig artikkel
Brautaset, Trygve; Borgos, Sven Even F.; Sletta, Håvard; Ellingsen, Trond E.; Zotchev, Sergey. (2003) Site-specific mutagenesis and domain substitutions in the loading module of the nystatin polyketide synthase, and their effects on nystatin biosynthesis in Streptomyces noursei. Journal of Biological Chemistry
Vitenskapelig artikkel
Brautaset, Trygve; Bruheim, Per; Sletta, Håvard; Hagen, Lars; Ellingsen, Trond E.; Strøm, Arne Reidar. (2002) Hexaene derivatives of nystatin produced as a result of an induced rearrangement within the nysC polyketide synthase gene in S. noursei ATCC 11455. Chemistry and Biology
Vitenskapelig artikkel
Brautaset, Trygve; Zotchev, Sergey. (2001) Cloning and sequencing of a polyene antibiotic biosynthetic gene cluster. QIAGEN Newsletter
Vitenskapelig artikkel
Brautaset, Trygve; Petersen, Steffen B.; Valla, Svein. (2000) In vitro determined kinetic properties of mutant phosphoglucomutases and their effects on sugar catabolism in Escherichia coli. Metabolic Engineering
Vitenskapelig artikkel
Winther-Larsen, Hanne C.; Josefsen, Kjell D.; Brautaset, Trygve; Valla, Svein. (2000) Parameters affecting gene expression from the Pm promoter in gram-negative bacteria. Metabolic Engineering
Vitenskapelig artikkel
Winther-Larsen, Hanne C.; Blatny, Janet M.; Valand, Bjørnar; Brautaset, Trygve; Valla, Svein. (2000) Pm promoter expression mutants and their use in broad-host-range RK2 plasmid vectors. Metabolic Engineering
Vitenskapelig artikkel
Brautaset, Trygve; Sekurova, Olga; Sletta, Håvard; Ellingsen, Trond E.; Strøm, Arne Reidar; Valla, Svein. (2000) Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455 : analysis of the gene cluster and deduction of the biosynthetic pathway. Chemistry and Biology
Vitenskapelig artikkel
Zotchev, Sergey; Brautaset, Trygve. (1999) Genetic manipulations of antibiotic-producing bacteria - an approach to creating new antibiotics. NBS-nytt
Vitenskapelig artikkel
Zotchev, Sergey; Brautaset, Trygve. (1999) Genetic manipulations of antibiotic-producing bacteria- an approach to creating new antibiotics. NBS-nytt
Vitenskapelig artikkel
Brautaset, Trygve. (1999) Enzyme Engineering. NBS-nytt
Vitenskapelig artikkel
Brautaset, Trygve; Petersen, Steffen; Valla, Svein. (1998) An Experimental study on carbon flow in Escherichia coli as a function of kinetic properties and expression levels of the enzyme phosphoglucomutase. Biotechnology and Bioengineering
Vitenskapelig artikkel
Blatny, Janet Martha; Brautaset, Trygve; Winther-Larsen, Hanne C.; Haugan, Kåre; Valla, Svein. (1997) Construction and use of a versatile set of broad-host-range cloning an d expression vectors based on the RK2 replicon. Applied and Environmental Microbiology
Vitenskapelig artikkel
Blatny, Janet Martha; Brautaset, Trygve; Winther-Larsen, Hanne C.; Karunakaran, Ponniah; Valla, Svein. (1997) Improved broad-host-range RK2 vectors useful for high and low regulated gene expression levels in gram-negative bacteria. Plasmid
Vitenskapelig artikkel
Blatny, Janet Martha; Karunakaran, Ponniah; Brautaset, Trygve; Knutsen, Torill Irene; Winther-Larsen, Hanne C.; Valla, Svein. (1997) New RK2 vectors useful in biotechnology and for analyses of RK2 replication and copy number control. Plasmid
Vitenskapelig artikkel
Blatny, Janet Martha; Brautaset, Trygve; Winther-Larsen, Hanne C.; Haugan, Kåre; Valla, Svein. (1997) Construction and use of a versatile set of broad-host-range cloning an d expression vectors based on the RK2 replicon. Applied and Environmental Microbiology
Vitenskapelig artikkel
Brautaset, Trygve. (1997) Construction and use of a versatile set of broad-host-range cloning and expression vectors based on the RK2 replicon. Applied and Environmental Microbiology
Vitenskapelig artikkel
Valla, Svein; Brautaset, Trygve. (1996) Metabolsk ingeniørkunst; Hva er det og hva kan det brukes til?. Kjemi
Vitenskapelig artikkel
Baptista, Antonio; Brautaset, Trygve; Drabløs, Finn; Martel, Paulo; Valla, Svein; Petersen, Steffen-B.. (1995) Electrostatic studies of carbohydrate active enzymes. Carbohydrate bioengineering : proceedings of an international conference
Vitenskapelig artikkel
Brautaset, Trygve; Standal, Rune; Fjærvik, Espen; Valla, Svein. (1994) Nucleotide sequence and expression analysis of the Acetobacter xylinum phosphoglucomutase gene. Microbiology
Vitenskapelig artikkel

Del av bok/rapport

Hesjedal, Maria Bårdsen; Brautaset, Trygve; Strand, Roger. (2023) Digital Life Norway - should biotechnology be transdisciplinary?. Edward Elgar Publishing
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
Stenseth, Nils Christian; Baalsrud, Helle Tessand; Jakobsen, Kjetill Sigurd; Brautaset, Trygve; Goksøyr, Anders; Jensen, Nina. (2021) Havgenomet – bevaring og bærekraftig bruk av marine genetiske ressurser i Norge.
Faglig kapittel
Brautaset, Trygve. (2017) Bioteknologi. Fagbokforlaget
Faglig kapittel
Almaas, Eivind; Brautaset, Trygve. (2015) Syntetisk biologi. Gyldendal Norsk Forlag A/S
Populærvitenskapelig kapittel/artikkel
Lale, Rahmi; Brautaset, Trygve; Valla, Svein. (2011) Broad-Host-Range Plasmid Vectors for Gene Expression in Bacteria. Springer Science+Business Media B.V.
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel
Brautaset, Trygve; Ellingsen, Trond Erling. (2011) Lysine: Industrial Uses and Production. Elsevier
Vitenskapelig Kapittel/Artikkel/Konferanseartikkel

Rapport

Wargelius, Anna; Alsheikh, Muath K; Gamlund, Espen; Tøndel, Camilla; Bartmann, Aina; Holst-Jensen, Arne. (2023) Genteknologi i en bærekraftig fremtid. Genteknologiutvalget - Norsk Offentlig Utredning (NOU)
Rapport
Naderi, Sheida; Visnes, Torkild; Brautaset, Trygve. (2021) Impact of DNA glycosylases on epigenetic regulation of gene expression via active DNA demethylation in human cells. NTNU Open
Mastergradsoppgave
Johansen, Finn-Eirik; Brautaset, Trygve; Aune, Marie Hjelmseth; Patriksson, Alexandra; Falkenberg, Liv Eggset; Kleppe, Rune. (2018) Centre for Digital Life Norway - Annual report 2017. Senter for Digialt Liv Norge
Rapport
Courtade, Gaston; Brautaset, Trygve; Aachmann, Finn Lillelund. (2018) An NMR investigation of lytic polysaccharide monooxygenases . Doktoravhandlinger ved NTNU (337)
Doktorgradsavhandling
Wimark, Odd-Gunnar; Brautaset, Trygve. (2016) Report: Synthetic biology - biosafety and contribution to addressing societal challenges Chapter 1: Synthetic Biology: Science, Experimental Approaches and Applications in Biotechnology. GenØk – Senter for biosikkerhet, Forskningsparken i Breivika, Postboks 6418, 9294 Tromsø
Rapport
Brautaset, Trygve. (1998) Phosphoglucomutase and its mutant derivatives as models for studies of carbon flow in Escherichia coli. NTNU Trondheim Norwegian University of Science and Technology
Doktorgradsavhandling

Undervisning

Emner

Formidling